Immunomonitoring services
The context of Clinical trials has recently changed, with new regulatory requirements and unmet industrial needs, including:
- New EMEA recommendations
- Better understanding of drug mechanisms of action
- High level of scientific evaluation
- Initial drug dose definition
- Necessary information for GO/NO GO decision
- Strategic discovery of Biomarker/Companion Diagnostic for Personalized Medicine
TcLand Expression, along with partners in the Center of Immunomonitoring Nantes Atlantic – CIMNA have developed a unique solution for clients requiring high value Immunomonitoring for their project, with Experts, Scientifics, knowhow and State of the Art technologies.
To ensure successful immune research investigation and clinical development, the CIMNA is:
- Your guide to the various Immunomonitoring solutions
- An offer of high quality analyses to meet regulatory requirements
CIMNA, a turnkey service integrating clinical trial design and monitoring, technical data management and logistics solutions
If you are interested in our services, or if you are a business partner (CRO) and you want to establish a preferred partner relationship with CIMNA, please contact: business@tcland-expression.com
For more information, please visit the CIMNA website: www.cimna.org. 
Highlights on Tclandscape: T cell repertoire analysis
A standardized process based on a dedicated and reliable data management and validation system
Applications
In vitro & preclinical analyses:
- Immune response detection & characterization
- Targeting immune populations for functional analyses
- Improvements in the understanding of the disease
- Screening drug candidates on T cell mobilization
- Diversity analyses (Epitope spreading, Clonality testing)
- Potential beneficial activity in animal model
- Dose response pattern
In early clinical development:
- Immune signature validation
- Immune response signature detection and Validation
- T cell mobilization kinetic
- Dose response Pattern identification
- Measurement, Prediction and Efficacy
- Predictive tools related to therapeutic intervention
- Prognostic tools related to disease
Data Analysis & Biostatistics
TcLandscape identifies the mobilized T cells selectively involved in the complex immune response among the millions of T cells available.
More precisely, this approach combines the analysis of Vb chain gene segment use, at the CDR3 length distribution level (Immunoscope/Spectratype) with a quantitative PCR assessment of all CDR3 length-restricted mRNAs in each family. The analyses can be performed in human, mouse, rat and primate models.
To explore the repertoire diversity, we have developed totally unsupervised statistical analysis methods which integrate the whole TcLandscape shapes in order to give "interpretable" data of the TcLandscape analyses. Such methods can be applied:
- For the follow-up of complex immune responses: e.g correlation between the TcLandscape shape and the MRI activity in MS patients
- To stratify groups of patients: these methods are used to explore and simplify complex multivariate data sets in order to provide a "projection" of the samples onto a reduced, easily visualized space using dedicated factorial techniques. Such discrimination tools are available in order to make group prediction